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ORIGINAL PAPER
 
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Resistance of gloves and protective clothing materials to permeation of cytostatic solutions

Sylwia Krzemińska 1  ,  
 
1
Central Institute for Labour Protection – National Research Institute, Łódź, Poland (Department of Personal Equipment)
2
Central Institute for Labour Protection – National Research Institute, Warszawa, Poland (Department of Chemical, Biological and Aerosol Hazards)
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ABSTRACT:
Objectives: The objective of the work was to determine the resistance of selected protective clothing and glove materials to permeation of cytostatics such as docetaxel, fluorouracil, and doxorubicin. Material and Methods: The following glove materials were used: natural rubber latex (code A), acrylonitrile-butadiene rubber (code B) and chloroprene rubber (code C). In addition, we tested a layered material composed of a non-woven polyester (PES), a polypropylene (PP) film, and a non-woven PP used for protective coats (code D). The cytostatics were analyzed by liquid chromatography with diode array detection. The tested samples were placed in a purpose-built permeation cell modified to be different from that specified in the standard EN 6529:2001. Results: The tested materials were characterized by good resistance to solutions containing 2 out of the 3 selected cytostatics: doxorubicin and 5-fluorouracil, as indicated by a breakthrough time of over 480 min. Equally high resistance to permeation of the third cytostatic (docetaxel) was exhibited by natural rubber latex, acrylonitrile-butadiene rubber, and chloroprene rubber. However, docetaxel permeated much more readily through the clothing layered material, compromising its barrier properties. Conclusions: It was found that the presence of additional components in cytostatic preparations accelerated permeation through material samples, thus deteriorating their barrier properties. Int J Occup Med Environ Health 2018;31(3)
CORRESPONDING AUTHOR:
Sylwia Krzemińska   
Central Institute for Labour Protection – National Research Institute, Department of Personal Equipment, Wierzbowa 48, 90-133 Łódź, Poland
Małgorzata Szewczyńska   
Central Institute for Labour Protection – National Research Institute, Department of Chemical, Biological and Aerosol Hazards, Czerniakowska 16, 00-701 Warszawa, Poland
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eISSN:1896-494X
ISSN:1232-1087