1.191
IF5
0.947
IF
15
MNiSW
149.8
ICV
ORIGINAL PAPER
 
 

4-Week inhalation toxicity of 2-methylnaphthalene in experimental animals

Radosław Świercz 1, 2  ,  
 
1
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Łódź, Poland
2
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, św. Teresy 8, 91-348, Łódź, Poland
Int J Occup Med Environ Health 2011;24(4):399–408
KEYWORDS:
ABSTRACT:
Objectives: This paper presents toxic effects of 2-MN in laboratory animals under conditions of 4-week inhalation exposure to 2-methylnaphthalene (2-MN) vapors. Materials and Methods: Male Wistar rats were exposed to 2-MN vapors at a nominal concentration of 0, 2, 10 or 50 mg/m3 in dynamic inhalation chambers for 4 weeks (6 h/day, 5 days/week). After 4 weeks of inhalation exposure the animals were necropsied. Blood samples were collected and selected organs were weighted and prepared for histological examinations. Results: The effects of the increased levels of exposure to 2-MN experienced by the experimental rats were as follows: a) increasing γ-glutamylotransferase activity, b) stimulation of the hematopoietic system, c) lower cholesterol concentrations, d) higher number of goblet cells in lobar bronchi, e) hyperplasia of hepatic bile ducts. Conclusion: Four-week exposure of the animals to 2-MN at 2 mg/m3 proved to be the no-observed-adverse-effect-level (NOAEL), while 10 mg/m3 appeared to represent the lowest-observed-adverseeffect- level (LOAEL).
eISSN:1896-494X
ISSN:1232-1087