Management of a patient with thermal burns and para-chloronitrobenzene poisoning
Yuanhai Zhang 1
Xingang Wang 2  
Liangfang Ni 1
Ruiming Jiang 1
Liping Liu 1
Chunjiang Ye 1
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Department of Burn and Plastic Surgery, Zhejiang Quhua Hospital, Quzhou, China
College of Medicine, Department of Burns & Wound Care Centre, 2nd Affiliated Hospital of Zhejiang University, Hangzhou, China
Int J Occup Med Environ Health 2014;27(5):882–887
Para-chloronitrobenzene (p-CNB), a hazardous and toxic substance, is widely used as an intermediary in chemical industries. p-CNB can cause methaemoglobinaemia due to electron-withdrawing properties of the nitro and chlorine groups. We present a case of a 23-year-old man suffering from thermal burns and p-CNB poisoning. In this case, severe methaemoglobinaemia was caused by the absorption of p-CNB through the burn wounds. Despite active treatment, such as the antidote of methylene blue, the patient’s methaemoglobinaemia progressed, with slowly increasing methaemoglobin (MetHb) level. This case highlights the complexity and difficulty of managing this type of injury. To our knowledge, this case can be the first case report describing methaemoglobinaemia induced by p-CNB in a patient with thermal burns.