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ORIGINAL PAPER
 
CC BY-NC 3.0 Polska
 
 

Pilot study of contact sensitization to rubber allergens and bisphenol A amongst dental students

 
1
Medical University – Sofia, Sofia, Bulgaria (Faculty of Medicine, Department of Hygiene, Medical Ecology and Nutrition)
2
Medical University – Sofia, Sofia, Bulgaria (Faculty of Dental Medicine, Department “Oral and Image Diagnostic”)
3
National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria (Laboratory of Allergy)
4
Medical University – Sofia, Sofia, Bulgaria (Faculty of Public Health, Department of Medical Ethics and Law)
Int J Occup Med Environ Health 2017;30(3):397–405
KEYWORDS:
TOPICS:
ABSTRACT:
Objectives: The aim of this study has been to evaluate the rate of contact sensitization to some rubber allergens and to bisphenol A (BPA) amongst students of dental medicine and dental patients. Material and Methods: A total of 50 participants were included in the study: 40 students of dental medicine exposed to the studied rubber allergens and BPA-based dental materials during the course of their education; 10 dental patients without occupational exposure to the latter substances served as a control group. All of them were patch-tested with the studied rubber allergens and bisphenol A. Results: Highest was the sensitizing action of carba mix, followed by benzoyl peroxide and mercapto mix. The sensitization rate for carba mix was significantly higher for dental students as well as for the whole studied population, if compared to the one for thiuram mix (Chi2 = 12.9, p < 0.001; Chi2 = 13.9, p < 0.001), bisphenol A (Chi2 = 8.9, p < 0.001; Chi2 = 11.9, p < 0.001), toluenesulfonamide formaldehyde resin (Chi2 = 10.7, p < 0.001; Chi2 = 13.9, p < 0.001) and benzoyl peroxide (Chi2 = 4.7, p = 0.03; Chi2 = 5.8, p = 0.016), and for dental patients, if compared to the one for mercapto mix (Chi2 = 7.07, p = 0.008). Concomitant positive skin patch-test reactions to carba mix and to benzoyl peroxide, and to all the studied allergens were established. Conclusions: Carba mix could be outlined as a sensitizer of paramount importance for dental students as well as for dental patients. Benzoyl peroxide was the second ranked sensitizer for dental students. Positive skin patch-test reactions to bisphenol A and toluenesulfonamide formaldehyde resin were established only among the group of dental students. Int J Occup Med Environ Health 2017;30(3):397–405
CORRESPONDING AUTHOR:
Maya Grigorievna Lyapina   
Medical University – Sofia, Faculty of Medicine, Department of Hygiene, Medical Ecology and Nutrition, 15 Blvd. “Acad. Ivan Evstr. Geshov,” 1431 Sofia, Bulgaria
eISSN:1896-494X
ISSN:1232-1087