Countries in transition, such as Serbia, have been going through obligatory system reforms, including the reform of the healthcare system. As a rule, occupational health becomes marginalized by the authorities who decide on medical care. In spite of the fact that this branch of medicine cares for working population that mostly carries the burden of transition, when material situation equals the existential minimum, its potentials are not recognized. On the other hand, the World Health Organization makes a remark that such population’s health is undermined now more than ever, and adopts a binding global plan for member countries and their experts in occupational health to take urgent measures for overall working people’s health according to their needs. It seems that former work method of biomedicine specialists could not realize such ambition. This paper discusses the possibilities of occupational health future orientation toward holistic medicine, for the sake of workers’ well-being and better quality of their lives, then creation of more humane society and vocational affirmation. Health promotion at workplace and salutogenic concept may have crucial roles. This concept is a huge challenge for academic public and vocational practitioners in poor countries in transition that are already burdened with the current economic and financial crisis. Each in their own way, helped by self-education and education, without big material investments, together they may take their countries to the road of health, the road still rarely taken, yet more secure.