Objectives: Subchondral carpometacarpal cysts are classic and almost pathognomonic lesions found in workers using vibrating instruments over prolonged periods of time. Materials and Methods: We present the case of a 53-year-old woman who worked for 30 years sewing shoe uppers, a task which required grasping fi rmly a pear-shaped handle awl and pushing it through the leather upper and the sole of the shoe, with combined fl exion and supination movement of the wrist. After approximately 20 years of working, the patient noted gradual onset of paresthesias in the dominant (right) hand, with increasing diffi culty in grasping the awl. Subsequent diagnosis of carpal tunnel syndrome was confi rmed by electrophysiologic testing and its surgical release was performed. Nevertheless, hand pain, paresthesias and weakness persisted. Results: Ultrasound of the snuffbox tendons excluded DeQuervain tenosynovitis. Radiographic imaging of the symptomatic hand showed carpometacarpal subchondral cystic formations. Conclusions: In addition to demonstrating the usefulness of radiographic imaging in patients with persistent hand pain post-carpal release, this case is important in illustrating that repetitive movements with high pressure over the palmar carpal area may cause bone cysts, even if the subjects do not use vibrating tools.