Objectives: The aim of this study was to assess the prevalence of self‑reported stress among informal caregivers of older adults living at home and to identify key factors associated with caregiving-related stress. Material and Methods: Between April 2024 and May 2025, a cross-sectional survey was conducted among 338 informal caregivers of individuals aged ≥60 years. Data were collected using the interRAI-Self-Reported Carer Needs (SCaN) tool. Logistic regression analyses were used to identify key stress-related factors. Results: Factors that significantly increase the odds of experiencing stress associated with caregiving include: being employed while providing care (OR = 3.03, 95% CI: 1.61–5.70), caring for a person with Alzheimer’s disease or other dementia (OR = 2.38, 95% CI: 1.24–4.54), lack of access to respite services (OR = 3.53, 95% CI: 1.92–6.49), spending >35 h/week on caregiving (OR = 2.27, 95% CI: 1.08–4.77), and the presence of mood-disorder symptoms in the carer (OR = 3.53, 95% CI: 1.92–6.49). Caregivers who felt their relatives’ needs were unmet were nearly 6 times more likely to report stress compared to those who felt otherwise (OR = 5.84, 95% CI: 1.48–23.01). Conclusions: Caregiver stress is a multifaceted phenomenon associated with numerous factors. This cross-sectional study identifies factors associated with the prevalence of caregiving stress, underscoring the need for a multidimensional approach to strengthen and optimize support systems for informal caregivers and the individuals they care for. Int J Occup Med Environ Health. 2026;39(6)