Objectives: The aim of the study was to analyze the determinants of prison inmates’ personal quality of life (PQoL). Material and Methods: Three hundred ninety men imprisoned in penitentiary institutions were assessed. Data were collected by means of the the Sense of Quality of Life Questionnaire, the General Self-Esteem Scale, the Social Support Scale, the Resiliency Assessment Scale, the Trait Personality Inventory, which have high validity and reliability. All models were specified in structural equations modeling using Mplus v. 8.2. Results: The positive correlates of PQoL are: self-efficacy, social support, and ego-resiliency. The negative correlate of PQoL is trait depression. The study confirmed that 2 factors affected ego-resiliency: self-efficacy and trait depression. Conclusions: All significant factors, such as self-efficacy, social support, ego-resiliency, or trait depression, should be taken into account in rehabilitation programs. Int J Occup Med Environ Health. 2023;36(2):291–302