Objectives: The aim of the study is to assess total fatigue levels among nursing staff who provide palliative care services, as well as to identify signifi- cant sociodemographic, occupational and cognitive predictors of self-perceived fatigue. Material and Methods: This cross-sectional study was car- ried out on a study group of 424 nurses that provide health care services in the palliative care units in Poland. The following scales were employed in the study: Fatigue Assessment Scale, Utrecht Work Engagement Scale, the Multidimensional Scale of Perceived Social Support, Perceived Stress at Work and Professional Quality of Life Scale. Results: The average total fatigue level in the study group was 20.78 (SD = 5.41). There was a positive relation- ship between gender, age, place of residence, marital status, education, perception of social support, occupational stress, and professional quality of life and perceived fatigue. In turn, there was a negative relationship between years of service and perception of social support in the "others" category and perceived fatigue. Conclusions: The study’s results show a significant relationship between perceived fatigue and sociodemographic, occupational and cognitive variables. Int J Occup Med Environ Health. 2025;38(1)