Objectives: The aim of the study is to assess total fatigue levels among nursing staff who provide palliative care services, as well as to identify significant sociodemographic, occupational and cognitive predictors of self-perceived fatigue. Material and Methods: This cross-sectional study was carried out on a study group of 424 nurses that provide health care services in the palliative care units in Poland. The following scales were employed in the study: Fatigue Assessment Scale, Utrecht Work Engagement Scale, the Multidimensional Scale of Perceived Social Support, Perceived Stress at Work and Professional Quality of Life Scale. Results: The average total fatigue level in the study group was 20.78 (SD = 5.41). There was a positive relationship between gender, age, place of residence, marital status, education, perception of social support, occupational stress, and professional quality of life and perceived fatigue. In turn, there was a negative relationship between years of service and perception of social support in the "others" category and perceived fatigue. Conclusions: The study’s results show a significant relationship between perceived fatigue and sociodemographic, occupational and cognitive variables. Int J Occup Med Environ Health. 2025;38(1):41–56