Objectives: Musicians represent a very specific professional group, which due to some occupational hazards is exposed to different health problems known as playing-related musculoskeletal disorders (PRMDs). The aim of this study was to assess correlations between the level of physical activity, and the occurrence of musculoskeletal pain among young instrumentalists. Materials and Methods: Total of 225 Polish musical school students were investigated. To assess the study participants' physical activity level, the moderate to vigorous physical activity (MVPA) index was used. To assess pain complaints on the side of the musculoskeletal system, Nordic Musculoskeletal Questionnaire (NMQ) was applied. The NMQ questionnaire was complemented by adding a visual-analog scale (VAS), which also allowed to assess pain intensity on a numerical scale 1-10. Results: The pain localized in neck, shoulders, upper and lower back was reported significantly more often by the participants who did not meet standard criteria for the recommended or minimal physical activity level. Conclusion: Performing the recommended health-oriented physical activity may reduce the prevalence of musculoskeletal pain in young musicians.