Objectives: Acute ischemic stroke stands as a significant contributor to high disability and mortality rates. Patient after stroke require vigilant supervision from general practitioners. Cardiovascular prevention emerges as a critical aspect. Physicians play a vital role in managing post-acute care and preventing secondary complications in patients with stroke after discharge. The aim of the study was to characterize and evaluate the cerebrovascular risk factors for stroke in patients under the care of general practitioners. Material and Methods: Data were collected from 277 patients after ischemic brain stroke under general practitioner care. Baseline demographic and clinical characteristics were gathered for all study participants. Results: Data were collected from 277 patients after ischemic brain stroke under general practitioner care. Baseline demographic and clinical characteristics were gathered for all study participants. Results: Gender distribution among the study cohort was 143 females (51.6%) aged mean (M) ± standard deviation (SD) 76.4±11.8 years and 134 males (48.4%), aged 78.5±11.9 years. Hypertension emerged as the most prevalent risk factor, affecting 75.8% of participants. Ischemic heart disease, lipid disorders, and atrial fibrillation, observed in 30.32%, 30.7%, and 29.6% of patients respectively. Diabetes mellitus was present in 23.1% of the cohort. The body weight was M±SD 76.9±16 kg, with BMI 27.6±6.6 kg/m². The presence of atrial fibrillation and chronic kidney disease showed statistically significant differences between survival and death groups. Statistically significant differences were observed in diastolic blood pressure in women vs. men (p = 0.0383). Regarding stroke severity, women presented with more severe symptoms (National Institutes of Health Stroke Scale score M = 10.5 vs. 8.3, p = 0.0163) and poorer functional outcomes in modified Rankin Scale (M = 3.3 vs. 2.8, p = 0.0062), a higher prevalence of hypertension and atrial fibrillation among women compared to men (35.0% vs. 17.5%, p = 0.0045). Conclusions: The authors’ findings highlight the necessity for sex-specific approaches in stroke management, particularly considering the impact of comorbid conditions such as hypertension and atrial fibrillation on stroke outcomes. Despite the availability of general guidelines, it would be valuable to develop specific guidelines for general practitioners on ischemic stroke risk factors. Int J Occup Med Environ Health. 2025;38(6)