Preliminary study to explore gene-PM2.5 interactive effects on respiratory system in traffic policemen
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Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety)
No. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China (Department of Gastroenterology)
Shanghai Jiao Tong University, Shanghai, China (Department of Cardiology, Xinhua Hospital, School of Medicine)
Corresponding author
Yuquan Xie   

Shanghai Jiao Tong University, Xinhua Hospital, School of Medicine, Department of Cardiology, 1665 Kong Jiang Road, Shanghai, 200092 China
Weimin Song   

Fudan University, School of Public Health, Department of Environment Health, Key Laboratory of Public Health Safety, 130 Dong An Road, Shanghai 200032, China
Int J Occup Med Environ Health. 2015;28(6):971-83
Objectives: Traffic-related particulate matter (PM) is one of the major sources of air pollution in metropolitan areas. This study is to observe the interactive effects of gene and fine particles (particles smaller than 2.5 μm – PM2.5) on the respiratory system and explore the mechanisms linking PM2.5 and pulmonary injury. Material and Methods: The participants include 110 traffic policemen and 101 common populations in Shanghai, China. Continuous 24 h individual-level PM2.5 is detected and the pulmonary function, high-sensitivity C-reactive protein (hs-CRP), Clara cell protein 16 (CC16) and the polymorphism in CXCL3, NME7 and C5 genes are determined. The multiple linear regression method is used to analyze the association between PM2.5 and health effects. Meanwhile, the interactive effects of gene and PM2.5 on lung function are analyzed. Results: The individual PM2.5 exposure for traffic policemen was higher than that in the common population whereas the forced expiratory volume in 1 s (FEV1), the ratio of FEV1 to forced vital capacity (FEV1/FVC) and lymphocytes are lower. In contrast, the hs-CRP level is higher. In the adjusted analysis, PM2.5 exposure was associated with the decrease in lymphocytes and the increase in hs-CRP. The allele frequencies for NME7 and C5 have significant differences between FEV1/FVC ≤ 70% and FEV1/FVC > 70% participants. The results didn’t find the interaction effects of gene and PM2.5 on FEV1/FVC in all the 3 genes. Conclusions: The results indicated that traffic exposure to high levels of PM2.5 was associated with systemic inflammatory response and respiratory injury. Traffic policemen represent a high risk group suffering from the respiratory injury.
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