REVIEW PAPER
Relationship between prenatal and postnatal exposure to BPA and its analogues (BPS, BPF) and allergic diseases
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1
Medical University of Lodz, Łódź, Poland
(Department of Pediatrics and Allergy, Copernicus Memorial Hospital)
2
Nofer Institute of Occupational Medicine, Łódź, Poland
(Department of Environmental and Occupational Health Hazards)
Online publication date: 2023-09-27
Corresponding author
Agnieszka Jankowska
Nofer Institute of Occupational Medicine, Department of Environmental and Occupational Health Hazards, św. Teresy 8,
91-348 Łódź, Poland
Int J Occup Med Environ Health. 2023;36(5):575-86
KEYWORDS
TOPICS
ABSTRACT
Bisphenols, endocrine disrupting chemicals, are widely used in daily life. Continued exposure during key developmental periods of life (pregnancy,
infancy and early childhood) can contribute to adverse health consequences such as decreased lung function, wheezing/asthma, the occurrence of
allergies or changes in immune system responses. The purpose of this review is to present the current state of knowledge on the effects of prenatal
or postnatal exposure to bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) on the development of allergic diseases in childhood. A com-
prehensive and systematic search of PubMed, Scopus and Web of Science databases was conducted. The review is restricted to studies published
since 2015, in English in peer-reviewed journals. Based on keywords, 2648 studies were identified and reviewed for eligibility. Finally, 8 epidemio-
logical studies were found to be appropriate for inclusion in this publication. The data collected in this review suggests that there is an associa-
tion between maternal exposure during pregnancy or childhood to BPA and the development of allergic diseases. Most studies reported positive
relationships between BPA exposure and at least one of the types of allergic disease. The paucity of studies and the observed differences in findings
regarding the association between prenatal/postnatal exposure to BPS and/or BPF do not allow firm conclusions to be drawn. Further research is
needed to identify the vulnerable population and the mechanisms responsible for the development of undesirable health consequences. Int J Occup
Med Environ Health. 2023;36(5):575–86