The global virtual reality (VR) market is growing surprisingly fast. As VR applications continue to expand into various areas of life, attention is being paid to issues related to user well-being. The danger lurking for users is the occurrence of simulator sickness and artificial reality sickness, collectively referred to as sensory conflict. As early as the 1950s, an attempt was made to study simulator sickness. Unfavorable psychophysical symptoms occurred in pilots using the first flight simulators. With the development of technology, the graphic and simulation capabilities of the various types of simulators are increasing. Easier access to simulators using first person view (FPV) and thus more outstanding research capabilities allow new studies related to the incidence of this disease to compare symptoms occurring during simulator sessions with those occurring during realworld endeavors. The primary purpose of the review is to bring together the latest reports on different types of sensory conflict concerning factors that are symptomatic in prediction and diagnosis. Heart rate, brain activity, stomach activity, and skin conductance seem to be the most adequate, objective indicators of subjects’ susceptibility to this phenomenon. In addition, it is intended to systematize concepts related to sensory conflict in the broadest sense. Int J Occup Med Environ Health. 2024;37(5):482–94