Objectives: The aim of this study is to establish which psychosocial factors at work are related to depression among female white-collar workers in Vilnius. Materials and Methods: The data was collected in a case-control study in 2002-2004. The cases were selected from patients treated at Vilnius mental health centers. The controls were randomly selected from employed Vilnius residents. A descriptive statistic and logistic regression was applied. Results: 3 psychosocial factors and possible confounders within the evaluated model were statistically reliable (model χ2: 44.47, p < 0.05 ). The adjusted odds ratio for uneven work distribution was 2.17 (95% CI: 1.38-3.51, p < 0.005), the odds ratio for possibility to control was 10.81 (95% CI: 2.13-54.71, p < 0.005), and the odds ratio for family esteem was 2.13 (95% CI: 1.01-4.59, p < 0.005). Conclusion: This study suggests that work distribution, possibility to control and family esteem, together with stressful life events and mental health disorders in the family, are related to depression among female white-collar workers.