1.191
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0.947
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15
MNiSW
149.8
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ORIGINAL PAPER
 
CC BY-NC 3.0 Polska
 
 

Molecular profile of sensitization in subjects with short occupational exposure to latex

Monica Lamberti 1  ,  
Antonia Feola 2,  
Nicola Medici 2,  
 
1
Second University of Naples, Naples, Italy (Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine)
2
Second University of Naples, Naples, Italy (Department of Biochemistry, Biophysics and General Pathology)
3
Sapienza University of Rome, Rome, Italy (Department of Medico-Surgical Sciences and Biotechnologies)
Int J Occup Med Environ Health 2015;28(5):841–848
KEYWORDS:
TOPICS:
ABSTRACT:
Objectives: We examined the prevalence of latex allergy in subjects with occupational exposure to latex allergens for less than 5 years, determining the disease spectrum in symptomatic workers. We identified the most frequent molecular allergens by Immuno- CAP (ICAP), correlating the findings with skin prick test (SPT) results. Material and Methods: Seven hundred twenty-three healthcare students using latex gloves on a regular basis were invited to participate in a baseline questionnaire screening. An ICAP serum test was performed only when a possible latex allergy was indicated by the questionnaire. Results: The total number of participants responding to the baseline survey was 619. Glove-related symptoms were indicated by 4% (N = 25) of the students. The most common symptom was contact dermatitis (N = 18, 72%). In 12 subjects, ICAP revealed a real sensitization to latex, with a recombinant latex allergen profile showing a high frequency for rHev b 6.01 specific immunoglobulin E (sIgE) (N = 9, 67%). In these individuals, skin symptoms were more prevalent than other types (88%). Conclusions: The combined positivity for rHev b 6.01, rHev 8 and rHev b 5 determined by ICAP identified 92% of latex-allergic subjects with short-term exposure to latex.
CORRESPONDING AUTHOR:
Monica Lamberti   
Second University of Naples, Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, School of Medicine, Viale dei Crecchi 16, 80100 Naples, Italy
eISSN:1896-494X
ISSN:1232-1087