Objectives: This paper is a report on the relationship between a sense of coherence (and its components) and work related patterns of behaviour in the group of nurses. Materials and Method: Data were collected by two questionnaires (Antonovsky’s Orientation Questionnaire and Work Related Patterns of Behaviour and Experience Questionnaire) in the sample of 331 volunteer nurses employed in three Polish general care hospitals. Results: The analysis of r-Pearson’s correlation and the linear multiple regression analysis revealed a strong relationship between the sense of coherence and healthy type of behaviour, and a strong negative relationship with a burnout type of behaviour. Conclusion: The results obtained in this study provide grounds for the conclusion that the sense of coherence correlates with healthy functioning at work in the group of nurses.